ADAMTSbc12

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ADAMTSbc12

An ADAMTSs family enzyme encoded by ADAMTS12 on chromosome 5q35, which is structurally similar to ADAMTS7. ADAMTS12 is expressed almost exclusively in the fetus, where it may play a role in lung development. It is expressed in gastric carcinomas but not in adjacent normal tissue. ADAMTS12 cleaves alpha-2 macroglobulin and aggregan, is involved in cell adhesion and has anti-tumourigenic properties.
References in periodicals archive ?
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity.