ADAM33

ADAM33

An enzyme of the metalloprotease-disintegrin family found mainly on the surface membranes of airway smooth muscle cells. There has been speculation that this enzyme may be involved in the remodelling of airway muscle layers that occurs in severe chronic ASTHMA.
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ADAM33 (ADAM Metallopeptidase Domain 33) is an asthma susceptible gene, and is associated with asthma and bronchial hyper-responsiveness (10).
In this study, we performed a meta-analysis to examine the association between ADAM33 polymorphism and risk of asthma in children.
The gene ADAM33 had been linked to the development of the condition.
Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease.
ADAM33 pertenece a la familia de proteinas transmembrana con dominio desintegrina y metaloproteinasa importantes en el mantenimiento y funcion de la matriz extracelular (8,9).
Entre ellos se han identificado como participantes de importancia ADAM33, NPSR1, PHF11, HLA-G mediante estudios de ligamiento genetico y mapeo fino.
For the study, US-based researchers Alireza Sadeghnejad, Jill Ohar, Eugene Bleecker and colleagues from the Wake Forest School of Medicine and Saint Louis University looked at a disintegrin and metalloprotease (ADAM) gene known as ADAM33 in 880 long-term heavy smokers.
ADAM33 is located on chromosome 20, and has been linked to asthma in previous studies.
Variations in a gene called ADAM33 may predispose a person to asthma.
The gene, called ADAM33, is thought to be one of the main causes of the development of chronic asthma, which tends to run in families.
The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation.