ADAMTSac2

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ADAMTSac2

An ADAMTSs family enzyme encoded by ADAMTS2 on chromosome 5qter which removes N-terminal propeptides of collagen types 1, 2 and 5 before fibril assembly. ADAMTS2 mutations have been linked to Ehlers-Danlos syndrome type VIIC and to bovine dermatosparaxis. ADAMTS2 is expressed in monocytes and macrophages, and expression can be induced in osteosarcoma cells by TGF-beta.