ADAMTSab1

(redirected from ADAM Metallopeptidase with Thrombospondin Type 1 Motif)

ADAMTSab1

An ADAMTS family protease encoded by ADAMTS1 on chromosome 21q21.2, which is antiangiogenic (ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, thrombospondin-1, or endostatin). ADAMTS1 is associated with acute inflammation and various inflammatory processes and with the development of cancer cachexia. ADAMTS1 expression is induced by IL1 and appears to be necessary for normal growth, fertility (it is up-regulated by progesterone during ovulation, and may play a critical role in follicular rupture), organogenesis and organ function. ADAMTS1 activity is blocked by some metalloprotease inhibitors, including TIMP-2 and TIMP-3. Thrombospondin proteolysis is decreased or absent in ADAMTS1 knock-out mice and associated with delayed wound closure and increased angiogenesis.
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cerevisiae); CAMK1D, calcium/ calmodulin-dependent protein kinase ID; TSPAN8, tetraspanin 8; LGR5, leucine-rich repeat-containing G protein--coupled receptor 5; THADA, thyroid adenoma associated; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif, 9; NOTCH2, notch 2; KCNQ1, potassium voltage-gated channel, KQT-like subfamily, member 1; MTNR1B, melatonin receptor 1B; CAPN10, calpain 10; ENPP1, ectonucleotide pyrophosphatase/phosphodiesterase 1.
cerevisiae); CAMK1D, calcium/calmodulin-dependent protein kinase ID; TSPAN8, tetraspanin 8; LGR5, leucine-rich repeat-containing G protein-coupled receptor 5; THADA, thyroid adenoma associated; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif, 9; NOTCH2, notch 2; KCNQ1, potassium voltage-gated channel, KQT-like subfamily, member 1; MTNR1B, melatonin receptor 1B; CAPN10, calpain 10; ENPP1, ectonucleotide pyrophosphatase/phosphodiesterase 1.
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