PSEN2

(redirected from AD5)
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PSEN2

A gene on chromosome 1q31-q42 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, or in linking chromatin to the nuclear membrane; it may also play a role in sorting proteins in the cytoplasm.

Molecular pathology
Defects in PSEN2 are a cause of Alzheimer disease type 4 and cardiomyopathy dilated type 1V.
References in periodicals archive ?
95% Subordinated Notes due 2019 (CUSIP: 05949R AD5 and P07785 AD3; ISIN: US05949RAD52 and USP07785AD38) (the "2019 Notes " and, together with the 2020 Notes, the "Notes "), from holders thereof (each, a "2019 Notes Holder " and collectively, the "2019 Notes Holders " and, together with the 2020 Notes Holders, the "Holders ") in an aggregate principal amount such that the aggregate principal amount of 2019 Notes accepted for purchase does not exceed (1) U.
95% Subordinated Notes due 2019 (CUSIP: 05949R AD5 and P07785 AD3; ISIN: US05949RAD52 and USP07785AD38) (the "2019 Notes" and, together with the 2020 Notes, the "Notes"), from holders thereof (each, a "2019 Notes Holder" and collectively, the "2019 Notes Holders" and, together with the 2020 Notes Holders, the "Holders") in an aggregate principal amount such that the aggregate principal amount of 2019 Notes accepted for purchase does not exceed (1) U.
The company also secured non-operated acreage in blocks A7 and AD5 (45% equity in each).