ACTH stimulation test


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ACTH stim·u·la·tion test

a test for adrenal cortical function; ACTH administered by bolus, continuous intravenous infusion, or intramuscularly, evokes an increase in plasma cortisol in normal persons; in adrenal cortical insufficiency, the expected increase in plasma cortisol is limited or nonexistent.

ACTH stimulation test

A test to determine the presence of adrenal insufficiency.

Patient care

Synthetic adrenocorticotropic hormone (ACTH) is injected intravenously, and the serum cortisol level is measured at timed intervals (30 or 60 min after the injection). A patient with normal adrenal function will respond to the test with increased serum cortisol levels above 18 µg/dl. Serum cortisol levels < 15 µg/dl are diagnostic of adrenal insufficiency. The test has been traditionally performed with an injection of 250 µg of ACTH, but studies have shown that 1 µg is an equally effective test dose.

Synonym: Cortrosyn stimulation test; cosyntropin stimulation test

ACTH stim·u·la·tion test

(stimyū-lāshŭn test)
Measurement of adrenal cortical function.
References in periodicals archive ?
5] Our study aims to diagnose adrenal insufficiency in critically ill patients on the basis of ACTH stimulation test.
No control dog had any clinical complaint or abnormality on urinalysis, complete blood count, serum biochemical panel, ACTH stimulation test, or adrenal ultra-sonographic examination.
9) Adrenal insufficiency was considered because of the poor response to the ACTH stimulation test.
The ACTH stimulation test is more reliable than an unstimulated test for assessing the capacity of the adrenal glands to respond to a stressor.
6) found that cortisol values in the 60th minute in a 1 mcg low-dose ACTH stimulation test (LDT) were significantly lower in the BD group than in the control group.
These symptoms indicate that the end of the induction has been reached and it's time for an ACTH stimulation test.
During the short postoperative ACTH stimulation test, cortisol values at 0, 30, 60, 90 and 120 minutes were 8.
We have not performed the high-dose ACTH stimulation test (250 [micro]g of synthetic ACTH 1-24 per 1.
Individuals were screened for diabetes and adrenal insufficiency, with basal cortisol levels and an ACTH stimulation test at the time of study entry and were excluded if either was identified.
The most dependable screening method for both hyper- and hypoadrenocorticism, however, is an ACTH stimulation test, which assesses the response of the adrenal glands to a test dose of the pituitary hormone.
4), the authors concluded that routine testing with the ACTH stimulation test is not cost-effective for the evaluation of hirsutism.