ACTH


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to ACTH: cortisol, ACTH stimulation test

ACTH

 

ACTH

Abbreviation for adrenocorticotropic hormone (also called corticotropin).
Synonym(s): corticotropin (3)

ACTH

adrenocorticotropic hormone; see corticotropin.

ACTH

(ā′sē′tē′āch′)
n.
A hormone produced by the anterior lobe of the pituitary gland that stimulates the secretion of cortisol and other hormones by the adrenal cortex. Also called adrenocorticotropin, corticotropin.

ACTH

abbreviation for adrenocorticotropic hormone.

ACTH

A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is regulated by corticotropin-releasing hormone (CRH).
Daily pattern ACTH levels vary over the space of a 24-hour day, peaking at 6–8 am and evening 6–11 pm; ACTH suppression or stimulation testing may be required to confirm the diagnosis of changes in adrenal function.
ACTH increased in Addison’s disease, congenital adrenal hyperplasia, Cushing disease, pituitary-dependent Cushing syndrome, ectopic ACTH-producing tumours, Nelson syndrome.
ACTH decreased in Secondary adrenocortical insufficiency, adrenal carcinoma, adenoma. 
Ref range < 120 pg/mL

ACTH

Adrenocorticotrophic hormone Endocrinology A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is in turn regulated by corticotropin-releasing hormone–CRH; ACTH is ↑ in pituitary-dependent Cushing syndrome Daily pattern ACTH levels vary over the space of a 24 hr day, peaking at 6–8 am and 6–11 pm; ACTH suppression or stimulation testing may be necessary to confirm the diagnosis of changes in adrenal function; ACTH is ↑ in Addison's disease, congenital adrenal hyperplasia, Cushing's disease, ectopic ACTH-producing tumors, Nelson syndrome; ACTH is ↓ in 2º adrenocortical insufficiency, adrenal carcinoma, adenoma. See Cushing syndrome.

ACTH

Abbreviation for adrenocorticotropic hormone.

ACTH

Adrenocorticotropic HORMONE. This hormone is produced by the pituitary gland, on instructions from the hypothalamus (the part of the brain immediately above the gland) when a stressful situation arises. ACTH is carried by the blood to the adrenal glands and prompts them to secrete the hormone cortisol into the bloodstream. ACTH is sometimes used as medication.

ACTH

see ADRENOCORTICOTROPIC HORMONE.

ACTH

Adrenocorticotropic hormone, a hormone normally produced by the pituitary gland, sometimes taken as a treatment for arthritis and other disorders.
Mentioned in: Anaphylaxis

ACTH

adrenocorticotrophic hormone

ACTH

adrenocorticotrophic hormone: see hormone, adrenocorticotrophic

ACTH,

ACTH

Abbreviation for adrenocorticotropic hormone.

ACTH (adrenocorticotropic hor-mone) (ədrē´nōkor´tikōtrō´pik hor´mōn),

n a hormone produced by basophilic cells of the anterior lobe of the pituitary gland that exerts a reciprocal regulating influence on the production of corticosteroids by the adrenal cortex.

ACTH

adrenocorticotropic hormone; produced by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of ACTH falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines. Called also adrenocorticotropin and corticotropin.
Its principal use is as a diagnostic agent: e.g. in the differentiation of primary adrenocortical neoplasia and adrenocortical hyperplasia.

ACTH assay
determination of plasma levels of ACTH may be used to identify pituitary-dependent hypo- or hyperadrenocorticism.
ACTH cells
ACTH gel
a commercially available form of ACTH in gelatin with prolonged action.
ACTH response test, ACTH stimulation test
measures the secretory capacity of the adrenal cortex in response to a supraphysiological dose of exogenous ACTH. This test is commonly used in the diagnosis of hyperadrenocorticism in dogs. An increased response is consistent with adrenocortical hyperplasia.
ACTH-secreting adenoma
References in periodicals archive ?
Pancreatic neuroendocrine tumors (NET) are a rare cause of ectopic ACTH syndrome.
An increased ACTH (92 pg/mL, reference interval, 5-27 pg/mL) confirmed that the Cushing syndrome was ACTH dependent.
Gruplarin hormon duzeyleri karsilastirildiginda kortizol, FSH ve serbest testosteron duzeylerinde istatistiksel olarak anlamli birfark bulunurken (p<0,05), ACTH ve diger cinsiyet hormon duzeylerinde istatistiksel olarak anlamli fark bulunmamistir (p>0,05).
In almost all cases, ACTH-producing hyperplasia or adenoma were appeared with high plasma ACTH level and persistent hyperpigmentation after several years of conventional steroid replacement and most of these were treated with transsphenoidal surgery.
On the other hand, opiate receptor antagonists have resulted in higher ACTH and/or cortisol response in people with a positive family history of alcoholism compared with those with a negative family history (King et al.
6) found that cortisol values in the 60th minute in a 1 mcg low-dose ACTH stimulation test (LDT) were significantly lower in the BD group than in the control group.
In the 1950s, clinical appreciation of the circadian organization of the HPA began to influence the design of treatment schedules involving ACTH and GCs to minimize risk of adrenal suppression and improve outcomes.
When using ACTH it is recommended that high dose, 150 units/m2/day be given in twice daily dosage for approximately two weeks, followed by taper as treatment response is evaluated.
A beneficial effect of glucocorticoid treatment over the longer term has never been shown clearly in MS nor has ACTH been revisited.
Bir calismada 3,75-42,5 Gy radyasyon alan hastalarin 5 yil sonra hepsinde BHE gelisirken, gonadotropinler %91, ACTH %77 ve TSH %42 oraninda eksik bulunmustur (15).
2001) show marked increases in brain CRH levels and plasma ACTH and cortisol concentrations, respectively, in the hours and days following the last exposure to alcohol.
Dexamethasone does not suppress cortisol and ACTH levels in critically ill patients to the extent found in controls (5,6).