ACTH


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ACTH

 

ACTH

Abbreviation for adrenocorticotropic hormone (also called corticotropin).
Synonym(s): corticotropin (3)

ACTH

adrenocorticotropic hormone; see corticotropin.

ACTH

(ā′sē′tē′āch′)
n.
A hormone produced by the anterior lobe of the pituitary gland that stimulates the secretion of cortisol and other hormones by the adrenal cortex. Also called adrenocorticotropin, corticotropin.

ACTH

abbreviation for adrenocorticotropic hormone.

ACTH

A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is regulated by corticotropin-releasing hormone (CRH).
Daily pattern ACTH levels vary over the space of a 24-hour day, peaking at 6–8 am and evening 6–11 pm; ACTH suppression or stimulation testing may be required to confirm the diagnosis of changes in adrenal function.
ACTH increased in Addison’s disease, congenital adrenal hyperplasia, Cushing disease, pituitary-dependent Cushing syndrome, ectopic ACTH-producing tumours, Nelson syndrome.
ACTH decreased in Secondary adrenocortical insufficiency, adrenal carcinoma, adenoma. 
Ref range < 120 pg/mL

ACTH

Adrenocorticotrophic hormone Endocrinology A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is in turn regulated by corticotropin-releasing hormone–CRH; ACTH is ↑ in pituitary-dependent Cushing syndrome Daily pattern ACTH levels vary over the space of a 24 hr day, peaking at 6–8 am and 6–11 pm; ACTH suppression or stimulation testing may be necessary to confirm the diagnosis of changes in adrenal function; ACTH is ↑ in Addison's disease, congenital adrenal hyperplasia, Cushing's disease, ectopic ACTH-producing tumors, Nelson syndrome; ACTH is ↓ in 2º adrenocortical insufficiency, adrenal carcinoma, adenoma. See Cushing syndrome.

ACTH

Abbreviation for adrenocorticotropic hormone.

ACTH

Adrenocorticotropic HORMONE. This hormone is produced by the pituitary gland, on instructions from the hypothalamus (the part of the brain immediately above the gland) when a stressful situation arises. ACTH is carried by the blood to the adrenal glands and prompts them to secrete the hormone cortisol into the bloodstream. ACTH is sometimes used as medication.

ACTH

see ADRENOCORTICOTROPIC HORMONE.

ACTH

Adrenocorticotropic hormone, a hormone normally produced by the pituitary gland, sometimes taken as a treatment for arthritis and other disorders.
Mentioned in: Anaphylaxis

ACTH

adrenocorticotrophic hormone

ACTH

adrenocorticotrophic hormone: see hormone, adrenocorticotrophic

ACTH,

ACTH

Abbreviation for adrenocorticotropic hormone.

ACTH (adrenocorticotropic hor-mone) (ədrē´nōkor´tikōtrō´pik hor´mōn),

n a hormone produced by basophilic cells of the anterior lobe of the pituitary gland that exerts a reciprocal regulating influence on the production of corticosteroids by the adrenal cortex.

ACTH

adrenocorticotropic hormone; produced by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of ACTH falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines. Called also adrenocorticotropin and corticotropin.
Its principal use is as a diagnostic agent: e.g. in the differentiation of primary adrenocortical neoplasia and adrenocortical hyperplasia.

ACTH assay
determination of plasma levels of ACTH may be used to identify pituitary-dependent hypo- or hyperadrenocorticism.
ACTH cells
ACTH gel
a commercially available form of ACTH in gelatin with prolonged action.
ACTH response test, ACTH stimulation test
measures the secretory capacity of the adrenal cortex in response to a supraphysiological dose of exogenous ACTH. This test is commonly used in the diagnosis of hyperadrenocorticism in dogs. An increased response is consistent with adrenocortical hyperplasia.
ACTH-secreting adenoma
References in periodicals archive ?
ACTH is produced by the pituitary gland in the brain.
Adrenal insufficiency is diagnosed when on stimulation test the peak serum cortisol is <500 nmol/L (18 [micro]g/dL), [18] alternatively it has been proposed that increment during ACTH stimulation test <250 nmol/L (9 [micro]g/dL) or basal cortisol <83 nmol/L (3 [micro]g/dL) can be considered as diagnostic of AI.
Ectopic ACTH-producing tumours produce ACTH, but they usually can not reduce the secretion of ACTH via classic negative feedback loops successfully.
En el caso de episodios infecciosos, sin importar el dia en que se presentaran, se determinaron los niveles de cortisol basal y despues del estimulo con ACTH (1 [micron]g); se considero que los pacientes con cortisol post-ACTH menor de 18 [micron]g/dL tenian supresion del eje HHS y se les administro suplencia de corticoides.
8 mg de dexametasona ([micro]g/dL) Cortisol despues de supresion con 8 15 mg de dexametasona ([micro]g/dL) ACTH ([micro]g/mL) <1.
Epitope Diagnostics has put great effort into the development of a simplified, robust, 2-hour ACTH assay with a high analytical sensitivity (LLOD: 0.
An increased ACTH (92 pg/mL, reference interval, 5-27 pg/mL) confirmed that the Cushing syndrome was ACTH dependent.
The plasma levels of ACTH and GH were determined using commercial ELISA kits (ACTH; Phenix Pharmaceuticals Inc.
Due to this enzymatic defect, cortisol is under-produced and the negative feedback control on ACTH is lost with consequently excess ACTH produced in order to normalize cortisol levels resulting in overproduction and accumulation of steroids precursors prior to the enzyme defect as well as hyperplasia of the adrenal cortex.
Glucocorticoids and possibly synthesis ACTH stimulate leptin secretion, and reversely leptin effects activation of adrenal glands [11,12].