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ACTG 076

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ACTG 076
AIDS Clinical Trial Group Study 076 AIDS A study that validated the prophylactic use of AZT in HIV-infected pregnant ♀–HIPW, orally during pregnancy, IV during labor, and subsequently to newborns ↓ by23 HIV-positivity in infants, saving 1 in 7 infants born to HIPW; ACTG 076 is the standard of care for these ♀. See AIDS, HIV.


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The ACTG 076 clinical trials showed that mothers who received AZT treatment during the last two trimesters of pregnancy and whose babies then received AZT for six weeks after birth had an eight percent chance of transferring the HIV infection to the child, while those who were not treated had approximately a twenty-five percent chance.
Since publication of the ACTG 076 trial, several studies have confirmed and extended these initial results (14,16-30).
In a study of pregnant women, ACTG 076, the estimated risk of mother-to-child transmission of HIV was less than 8% in zidovudine-treated infants (antenatal, perinatal, and neonatal drug administration) versus almost 25% in the placebo group.
 
 
 
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