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ACAPSA clinical trial designed to assess
(1) the effects of lovastatin and warfarin on carotid atherosclerosis progression in asymptomatic high-risk individuals, and
(2) the effect of the treatments on the incidence of major atherosclerotic events.
Conclusion Mean LDL fell by 28% at 6 months in the lovastatin group vs. placebo, with regression of early atherosclerosis after 12 months in the lovastatin-only group.