ACADM


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ACADM

A gene on chromosome 1p31, which encodes a medium-chain-specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase, which catalyses the initial step of the mitochondrial fatty acid beta-oxidation pathway.

Molecular pathology
ACADM defects cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterised by hepatic dysfunction, fasting hypoglycemia and encephalopathy, which causes death in infancy.
References in periodicals archive ?
Total RNA from different adipose tissues, LD and other organs were analyzed by qRT-PCR for the following genes: PPAR[gamma], FASN, ACADM.
PPAR[gamma], FASN, and ACADM mRNA expression in adipose tissue and LD of Yanbian yellow cattle
PPAR[gamma], FASN, and ACADM were expressed in adipose tissues and LD of Yanbian yellow cattle, as shown in Figure 2, 3, and 4.
FASN and ACADM mRNA expressions were detected in the same samples, though FASN gene showed a trend for higher expression in adipose tissue than in LD (Figure 3); ACADM gene showed a trend for higher expression in adipose tissue than in LD, though the difference was not statistically significant (Figure 4).
PPAR[gamma], FASN, and ACADM mRNA expression levels in adipose tissues and LD of Yan yellow cattle
As shown in Figure 2, 3, and 4, PPAR[gamma], FASN, and ACADM mRNA expression were detected in Yan yellow cattle.
ACADM gene was expressed in all the adipose tissues and LD and the expression level in LD was higher than that in adipose tissues, though the difference was not statistically significant (Figure 4).
Comparison of PPAR[gamma], FASN, and ACADM mRNA expression levels between Yanbian yellow cattle and Yan yellow cattle in adipose tissue and LD