GCDH

(redirected from ACAD5)

GCDH

A gene on chromosome 19p13.2 that encodes glutaryl-CoA dehydrogenase, a member of the acyl-CoA dehydrogenase family, which catalyses the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.

Molecular pathology
Defects in GCDH cause glutaric aciduria type 1.