ABL1

ABL1

A gene on chromosome 9q34.1 that encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, cell division, cell adhesion and stress response. ABL1 is negatively regulated by its SH3 domain.

Molecular pathology
Deletion of the SH3 domain turns ABL1 into an oncogene; the t(9;22) translocation results in the head-to-tail fusion of BCR and ABL1, which is present in many cases of CML.
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50] values ranging from 1 to 10 [micro]M, and was also an effective inhibitor of several important kinases such as ABL1, CDK4, CHK1, PKC, c-MET, FGFR, and others (Villalonga et al.
Exposing these cancer cells to amounts of noradrenaline similar to those found in ovarian tissues both under normal and stressed conditions showed that the noradrenaline levels during stress activated Src pathways that in turn caused a cascade of kinase pathways to be activated, including KIT, EGFR, ABL1, and IGF-1.
International Scale (IS)-Standardized BCR-ABL1 Digital Polymerase Chain Reaction (dPCR) Assays Using ABL1, BCR, and GUS Control Genes for Measuring Deep Molecular Response (MR) in Chronic Myeloid Leukemia (CML) (Abstract #136, Oral Presentation, Saturday, December 5, 4:45 pm EST)
Fluorescence in situ hybridization evaluation for a BCRABL1 rearrangement was performed (with Vysis LSI BCRJ ABL1 Dual Color, Dual Fusion Translocation Probe, catalog number 05J82-001, Abbot Vysis Molecular, Abbot Park, Illinois) and the rearrangement was seen in 95 of 100 nuclei (Figure 3, b).
To generate a reproducible and lasting source of reference material, synthetic and nuclease-resistant ABL1, BCR, and BCR-ABL1 transcripts were prepared on a large scale with the validated ARQ manufacturing process (see Figs.
CACNA1D, EDNRA, KCNG2, NR3C2, PDE4D, ACE, ADRA1B, ADRB3, KCNJ11, ADRAJD Cardiac dilation Imipramine EPO, NOS1 Pulmonary hypertension EtOH-Fr EDNRB, FTGER3, PDE5A Pulmonary hypertension Imipramine EPO, EDNRB, FLT3, ABL1, EDNRA, ADRA1B, ADRB3, ADRA1D Increased levels of alkaline EtOH-Fr VEGFA phosphatase Bold indicate that these genes are prevalent in several disease clusters.
Standard quantitative analyses of BCR-ABL [fusion gene of BCR [5] (breakpoint cluster region) and ABL1 (c-abl oncogene 1, receptor tyrosine kinase)] and the total number of ABL transcripts were performed as previously described (17).
van de Locht, Nijmegen, The Netherlands) (24) and ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1) (25) were used to normalize ZAP70 and LPL expression.
Recalled hand trucks have model numbers 12-301 ABL and 12-301 ABL1 and were manufactured from January 2009 to October 2011.
OncoMap Genes and Mutations (a) Gene Mutations ABL1 16 AKT1 1 AKT2 2 APC 13 BRAF 50 CDK4 1 CDKN2A 11 CSF1R 7 CTNNB1 33 EGFR 51 ERBB2 8 FGFR1 2 FGFR2 6 FGFR3 8 FLT3 9 GNA11 2 GNAQ 3 GNAS 3 HRAS 16 IDH1 3 IDH2 2 JAK2 1 JAK3 3 KIT 27 KRAS 24 MAP2K1 7 MET 6 MLH1 1 MYC 6 NPM1 3 NRAS 22 PDGFRA 20 PIK3CA 23 PIK3R1 14 PTEN 15 RB1 11 RET 14 SRC 1 STK11 12 TP53 7 VHL 7 (a) OncoMap 4 consists of 439 assays designed to interrogate 471 unique mutations in 41 cancer genes.
Sequencing data from SCLC samples revealed a wider spectrum of mutations, with variants detected in TP53 (57%); RB1 (11%); ATM, cMET, and PTEN (6-7%); BRAF, SMAD4, and KRAS (3-4%); and ABL1, APC, CTNNB1, EGFR, FBXW7, FGFR2, HNF1A, HRAS, JAK3, MLH1, and PIK3CA (1-2%).