ABECB


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ABECB

Acute bacterial exacerbation of acute bronchititis
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In these studies, FACTIVE tablets demonstrated excellent clinical response rates at test-of-cure visit for CAP and ABECB as good as comparators including clarithromycin, levofloxacin, amoxicillin/clavulanate, ceftriaxone and oral cefuroxime.
In the second study involving 360 patients with ABECB, once-daily FACTIVE tablets (320 mg) for five days were clinically equivalent to levofloxacin (500mg) taken once-daily for seven days.
With unproven safety profiles, are new agents the best choice for ABECB therapy?
However, the increased incidence of gastrointestinal adverse events at the 600 mg dose, as well as the lower efficacy observed at the 150 mg dose, may support the selection of a 300 mg QD dose in the treatment of ABECB in future clinical studies.