ABCG2


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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
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The cells cultured over AM + 3T3 showed the expression of p63 and ABCG2 till 21 days of incubation by immunohistochemistry and Western blot.
Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle.
WPE-stem cells also highly express the prostate SC markers ABCG2 [ATP-binding cassette, subfamily G (WHITE), member 2] and BMI-1 [BMI1 polycomb ring finger oncogene] [see Supplemental Material, Figure 1, available online (doi: 10.
Reverse transcriptase PCR, immunohistochemistry, Western blotting for ABCG2, P63, Cnx43 and K3/K12 were done.
Mutant ABCG2 can also be less efficient at pushing drugs out of the intestine, which can also cause diarrhea, according to Sharyn Baker, Pharm.
Other studies have identified a minor population of melanoma cells with enhanced tumorigenic potential that stains positively for CD133 or the ABC transporter protein ABCG2, (121) or have identified a side population by using the flow cytofluorimetric technique based on heightened capacity of stem cells to efflux fluorescent dyes.
Cattle Multiple breeds Linear regression PLA2G5, ATP1A1, (1,500) DAG1 Belgian Blue (26) Case-control ATPA2A1 (ASSHOM/ASSIST) Belgian Blue (31) Case-control SLC6A5 (ASSHOM/ASSIST) Italian Chianina Case-control ABCA12 (12) (ASSHOM/ASSIST) Holstein cows Case-control (Plink) EDN2, SOD1, (245) PARP1 etc Black/Red Angus Case-control (Plink) MC1R (76) Holstein bulls Linear regression/ DGAT1, ABCG2, (5,360) Bayesian methods Integrin jj2 etc.
The mutation is an event in which a single amino acid changes in the structure of the ABCG2 protein, which then acts as a pump to transfer out the various anticancer drugs," explains Assaraf.
Alteration in phenotype of LNCaP cells after exposure also indicate that APOPTONE may increase the susceptibility of tumor cells to chemotherapeutic agents by down-regulating the gene for the multi-drug resistant protein ABCG2, originally known as the Breast Cancer Resistance Protein (BCRP1).
Data were also presented showing that APOPTONE may increase the susceptibility of tumor cells to chemotherapeutic agents by down-regulating ABCG2, the gene for the multi-drug resistant protein MDR2, also known as the Breast Cancer Resistance Protein (BCRP).
Data also are being presented showing that APOPTONE may increase the susceptibility of tumor cells to chemotherapeutic agents by down-regulating ABCG2, the gene for the multi-drug resistant protein MDR2, also known as the Breast Cancer Resistance Protein (BCRP).