ABCC4


Also found in: Wikipedia.

ABCC4

A gene on chromosome 13q32 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC4 is thought to play a role in cellular detoxification as an organic anion pump.
References in periodicals archive ?
ABCC4 and SLCO2A1 mRNAs are expressed in a stage and cell type specific manner in the uterine endometrium during pregnancy, and their expression is increased by interleukin-1[beta] (IL1B) during the implantation period [8].
Our previous study has shown that the patterns of ABCC4 and SLCO2A1 expression during pregnancy were biphasic with the highest levels on D12 and D90 of pregnancy [8].
Expression of ABCC4 and SLCO2A1 mRNA and protein has also been shown in conceptus tissues and chorioallaltoic tissues [8].
ABCC1 and ABCC9 mRNAs were expressed by the same cell types, which express ABCC4 [8].
The IL1B also increases the expression of many endometrial genes, including IL1B receptor genes IL1 receptor 1 (IL1R1) and IL1RAP, PG transporter genes ABCC4 and SLCO2A1, a calcium binding protein gene S100 calcium binding protein G (S100G), and a small lipid binding protein gene salivary lipocalin 1 (SAL1) [8,28].
Our previous study has also shown that IL1B, but not estrogen, increases the expression of ABCC4 and SLCO2A1 mRNAs, which show higher levels of endometrial expression on D12 of pregnancy than during the estrous cycle in pigs [8].
El proceso de absorcion se realiza por transporte activo usando transportador PepTl [23], mientras que los transportadores ABCC3 y ABCC4 son los responsables de la excrecion [24],
Experimentalmente esta demostrado que cefadroxilo es sustrato del transportador de absorcion PepTl y de los transportadores de excrecion ABCC3 y ABCC4 y algunos entes regulatorios limitan las bioexenciones a aquellos farmacos que atraviesan la barrera intestinal solo por difusion pasiva, por lo que cefadroxilo no podria ser candidato a bioexencion.
Oral availability of Cefadroxil depends on ABCC3 and ABCC4.
Both organic anions and xenobiotics in the blood use the same organic anion transporters (OATs) for entry into proximal tubule cells and they then exit these cells through ATP dependent ABCC2 (MRP2) and ABCC4 (MRP4), cassette transporters located at the luminal membrane of the cells (Sekine et al.