ABCC1


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ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.
References in periodicals archive ?
Patients who had the variant allele of either ABCB1 rs3842 or ABCC1 rs212090 had a significantly increased risk of developing lung cancer, with the former variant particularly associated with an increased risk of cancer in women and in individuals under age 60 years.
Another widely studied transporter is ABCC1, which is also known as MRP-1.
25 ng of HepG2 total RNA was created for all ABC transporters except ABCA6, ABCA8, ABCA9, ABCA10, ABCB11, ABCC1, and ABCC7.
Multidrug resistance protein 1 (MRP1), which is structurally similar to P-gp, is the product of the ABCC1 gene and can export anthracenedione, anthracycline, epipodophyllotoxin, vinca alkaloids, etc.
The primers were: ABCB1, 3977 5'-GCTCGTCCCCTTGTTAG-ACAGCC-3' 3999 and 4186 5-CGTGCCATGCTCCTTGACTCTGC-3' 4164; ABCC1, 4381 5'-CCTGGAGCTGGCCCACCTGA-3' 4400 and 4551 5'-GCTGCCGTGGCCTCATCCAA-3 4532; ABCC2, 2075 5-GCAGCAGGTCAGAGTGTGGTTTC-3' 2097 and 2383 5-GTGATTCT-TCCACAAGCCCCAGG-3' 2361; GAPDH, 961 5-AACAGCGACACCCA-CTCaC-3' 980 and 1045 5'-CATACCAGGAAATGAGCTTGACAA-3' 1022.