ABCB5


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ABCB5

A gene on chromosome 7p21.1 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, which participates in ATP-dependent transmembrane transport of a range from small ions, sugars and peptides to complex biomolecules.

Molecular pathology
The ABCB5 protein product is responsible for the doxorubicin resistance in some malignant melanomas.
References in periodicals archive ?
Recently, we described another lignan, (-)-sesamin, whose cytotoxicity is not curtailed by both P-glycoprotein and its close relative, ABCB5 (Saeed et al.
In a collaborative effort between a number of institutions in Massachusetts, US, researchers uncovered that LSCs express a molecule called ABCB5 which plays a role in maintaining the population of LSCs in the eye, keeping them in a 'resting' state by avoiding programmed cell-death.
Mice lacking the ABCB5 gene were unable to maintain populations of LSCs and their corneas were unable to heal effectively after injury.
Washington, July 3 ( ANI ): Scientists have discovered a way to regrow human corneal tissue using hard-to-find limbal stem cells known as ABCB5 molecule.
The researchers were able to use antibodies detecting ABCB5 to zero in on the stem cells in tissue from deceased human donors and used them to regrow anatomically correct, fully functional human corneas in mice.
BOSTON, June 8, 2011 /PRNewswire-USNewswire/ -- Researchers at Children's Hospital Boston have found a marker called ABCB5 that both tags a small proportion of cells within colorectal cancers and fuels resistance in those cells to standard treatments.
41) The ABCB5 transporter belongs to the superfamily of integral membrane proteins (Figure 3, C).
The team from Harvard University found that a protein called ABCB5 can identify cancer stem cells and developed an antibody that neutralized their action, halting tumor growth in mice that had been injected with human melanoma cells.
Washington, June 9 (ANI): Scientists at the Children's Hospital Boston have identified a protein called ABCB5 in colorectal cancers that increases treatment resistance and recurrence of the tumour.
The authors (120) further showed that administration of a monoclonal antibody against ABCB5 significantly reduces melanoma growth.
The ABCB5 technology has been licensed and is currently in clinical drug development.