ABCB1

ABCB1

A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.

Molecular pathology
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.

ABCB1

Member 1 of the B subfamily of ABC TRANSPORTER PROTEINS. Also known as MDR1. Polymorphism of the gene for ABCB1 is associated with multi-drug resistance in the treatment of a range of diseases including epilepsy, various cancers, rheumatoid arthritis and inflammatory bowel disease. Clinical experience has shown that several drugs used to treat cancer may become ineffective simultaneously in spite of having unrelated chemical structure. This multi-drug resistance was shown to be due to enhanced expression of ABCB1 which was using ATP-derived energy to export drugs from the cytosol to the extracellular fluid.
References in periodicals archive ?
Among the drug transporters shown to play a key role in drug disposition, P-gp encoded by the ABCB1 gene is one of the most extensively studied.
Other reports have also implicated a number of other SNPs in genes of the folate metabolism pathway, including MDR1, ABCB1, RFC, ATIC, TS enhance region (TSER), adenosine monophosphate demaniase (AMPDA) and inosine triphosphat pyrophosphate (ITPA) (12-16).
Effect of the ATP- binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/-(triple-knockout) and wild-type mice.
in other genes, such as ABCB1, may also contribute to variability in
The gene ABCB1 may encode the production of compounds essential to this process.
Some areas investigated include the role of serotonin receptors and GABA and glutamate in pain, riboflavin as an anti-nociceptive and anti-inflammatory adjuvant, polymorphisms of the opioid metabolism-related gene ABCB1, and the advantage of using wild-derived mouse strains for pain-related studies.
those tumor cells that survive in the presence of Taxol), the researchers identified seven peptides that allowed for increased Taxol resistance, one of which consistently had the highest survival rate and was linked to upregulation of the gene ABCB1 (also known as MDR1 for multiple drug resistance).
The C-GAAP is a clinically validated diagnostic test that identifies patients with genetic variations in CYP2C19, a gene whose effect is described in clopidogrel's label, and ABCB1, a gene that is unique to Transgenomic's panel and is covered by issued and pending patents owned by Transgenomic.
Professor Irinel Popescu, Fundeni Clinical Institute, Bucharest, Romania, 'Association of de novo donor specific anti-HLA antibodies and liver allograft outcome according to ABCB1 and CYP3A5 genotypes'
7 percent) of 1048 patients through a combination of overexpression of ABCB1 and either high expression of TUBB3 or low expression of topoisomerase 2A (TOPA2A), suggesting resistance to taxanes and anthracyclines.
There is currently no evidence supporting an influence of polymorphisms of the gene ABCB1 [ATP-binding cassette, sub-family B (MDR/TAP), member 1] [8] (the P-gp-encoding gene) (4) on SRL pharmacokinetics and clinical outcomes in kidney transplant patients.
2008), both phase II DME genes; ABCB1 [ATP-binding cassette, subfamily B, member 1; also named multidrug resistance 1 (MDR1)] (Tang et al.