ABCA1


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ABCA1

ATP-binding cassette transporter ABCA1. A protein encoded by ABCA1 on chromosome 9p31, which is a major regulator in transporting cholesterol and phospholipids out of cells that later bind with ApoA1 in the circulation.
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Next, the researchers tried treating old macrophages with an LXR agonist; these drugs are known to enhance cholesterol transport from macrophages by turning on the ABCA1 gene.
Some rare disorders of apoAI, LCAT and ABCA1 result in very low concentrations, typically an HDL cholesterol <0.
Cholesterol feeding in rabbits has been documented to increase cellular levels of oxysterols, which rapidly increase expression of hepatic LXR and its target genes, such as ABCA1 and CETP.
Because it is known that carotenoid transport into enterocytes is mediated by the cholesterol transporters SR-BI, NPC1L1 and ABCA1 (Reboul and Borel 2011; During et al.
Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease.
A gene, known as ABCA1, is at the crossroads of the process that shuttles intracellular cholesterol outbound.
The absorption of dietary fat is regulated by numerous genes at the erythrocyte level namely the ATP binding cassette (ABC) transporters ABCA1, ABCG5, ABCG8 (11).
The second is the ABCA1 transporter, originally identified as a genetic defect in Tangier disease (Lawn et al.
Mutations in ABCA1 are responsible for Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A-I, accumulation of sterol in tissue macrophages, and prevalent atherosclerosis.
The effects were specific, with no significant effects being observed on ABCA1, ABCG1 or LXR mRNA levels.
Quercetin-3-O-glucuronide induces ABCA1 expression by LXRalpha activation in murine macrophages.
Inhibition of miR-33a and miR-33b increases cholesterol efflux in the liver and peripheral macrophages through upregulation of the target gene ABCA1.