ABCG2

(redirected from ABC transporter)
Also found in: Wikipedia.

ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
References in periodicals archive ?
ABCA1, a member of the ABC transporter family, facilitates the active transport of cholesterol and phospholipids from the intracellular compartments of peripheral cells to the lipid-poor nascent HDL particle (7), thus representing the first step of the RCT pathway.
Detecting the interaction of drug candidates with a wide variety of ABC transporter proteins, including MDR1, MRPs and MXR; * Testing the target binding of MDR modulators; * Predicting penetration of drug candidates through pharmacological barriers; * Predicting penetration of intracellularly active cytostatics through the membranes of tumor cells.
Gene expression analysis of selected genes in the liver and large intestine demonstrated increased levels of IL-10, Liver X Receptor (LXR), and ABC transporter G1.
These important findings underscore the need for a sensitive, rapid, and accurate method for quantification of ABC transporter expression, and a systematic investigation of these molecules in human tissues is thus warranted.
Galbraith as Active Pass fortifies its position as the industry leader in ABC transporter drug discovery.
These results prompted us to consider that transgelin 2 may promote the resistance of breast cancer cells to paclitaxel by increasing the expression of ABC transporter protein.
chief executive officer of NeoGenesis, said, "We are very pleased to be involved in a collaborative effort with Active Pass, the foremost company in ABC transporter drug discovery.
The ABC transporter family is considered as one of the largest protein families in biology (Dassa and Bouige, 2001).
The new gene signature panel for ABC transporter genes enables researchers to analyze the mechanisms that regulate the transport of substances across the cell membrane, mediate export of drugs in tumor cells, and affect drug resistance.
SOLVO's leading in vitro assay systems are designed to detect interaction of test compounds with a wide array of ABC Transporter proteins found at these vital pharmacological barriers.
2007, Quantitative structure-activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDRl).