SUMF1

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SUMF1

A gene on chromosome 3p26.1 that encodes sulfatase-modifying factor 1, which oxidises a cysteine residue in substrate sulfatases (e.g., ARSA, ARSE, GALNS, STS), thereby activating them. It is inhibited by SUMF2.
 
Molecular pathology
Defects in SUMF1 cause multiple sulfatase deficiency.