AA protein


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AA protein

a product of α-globulin and the major protein component of reactive amyloid.
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Cleavage in circulating monocytes /macrophages results in the generation of smaller fragments, called AA protein that can then deposit in the tissues.
13,14) Some of the predisposing diseases, such as rheumatoid arthritis and tuberculosis, are very prevalent in the adult population; therefore, immunohistochemical demonstration of AA protein in tissue amyloid or a careful evaluation for other types of amyloidosis should be performed before concluding that the type of amyloidosis is AA.
4-6 In the second most common type of amyloidosis worldwide, AA, targeting the underlying inflammatory disease leads to a reduction of the circulating fibril precursor, serum AA protein.