A375

A375

A human amelanotic melanoma cell line used in cytokine research, as it is not influenced by many biomolecules—e.g., prostaglandin E2; lectins; bacterial endotoxins and cytokines such as IL2, TNF; interferons or colony stimulating factors. A375 cells are extremely sensitive to growth-inhibitory effects of oncostatin M.
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For melanoma, similar levels of in vitro sensitivity were observed in different genetic subtypes with LY2835219 showing single-agent activity in the A375 BRAF mutant melanoma xenograft model with daily oral dosing at 45 or 90 mg/kg.
Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway.
Using the A375 human melanoma cell line in SCID mice, the Company demonstrated that vitiligo-derived IgG preparations can prevent the growth of melanomas in a dose dependant manner.
Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells.
A180: Bcl-2 antisense oligodeoxynucleotides and GSH depletion-induced sensitization to chemotherapy lead to complete regression of A375 melanoma xenografts.
In a number of human melanoma model experiments, using SCID mice and the A375 human melanoma cell line, the Company demonstrated that vitiligo-derived IgG preparations can prevent, in a statistically significant manner, the growth of subcutaneous melanomas (tumors).
Three of the lenses are drop-in replacements for Kodak's(R) discontinued A390, A397, and A375 lenses.
Proteomics analysis of' kojic acid treated A375 human malignant melanoma cells.
Moreover, POL showed remarkable anti-HSV-II activity towards Vero cells, cytotoxicity towards human melanoma A375 cells and induced apoptosis in a caspase-dependent manner.
The colo 205, WEHI-3 and HL-60 cells were cultured in RPMI 1640 medium, to the Hep G2, B16-F1 and A375 S2 cells were cultured in Dulbecco's minimal essential (DMEM) medium supplemented with 10% fetal bovine serum, 2 mM L-glutamine, and 2% penicillin-streptomycin (10,000 U/ml penicillin and 10mg/ml streptomycin).