A2058

A2058

A cell line established from a melanoma metastasis of a 43-year-old. The cells are highly invasive and are a source of proteins (e.g., autocrine motility factor (AMF)—autotaxin) associated with invasion—e.g., interstitial collagenase, TIMP-2.
References in periodicals archive ?
Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells.
Mutations of A2058, A2059, and other 23S rRNA residues within the macrolide-binding site can confer a high-level resistance to macrolides in several bacterial species, including M.
Both erythromycin and telithromycin bind to residues A2058 and A2059 in the central loop of domain V of the 23S ribosomal RNA (rRNA) in the 50S ribosomal sub-unit, and interact at residue A752 of hairpin 35 of Domain II of the 23S rRNA; however, telithromycin interacts more strongly than erythromycin at this site.