alpha 1 antitrypsin

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alpha 1 antitrypsin

A 54 kD glycoprotein that inhibits proteolytic enzymes (proteases),trypsin, chymotrypsin, elastases in lysosomes, plasmin, thrombin, collagenase, and others. Serum A1AT increases nonspecifically during inflammation and is a so-called acute phase reactant.
Elevated A1AT Inflammation, liver injury, increased oestrogen, pregnancy, malignancy, corticosteroid therapy.
Reduced A1AT Heterozygous A1AT deficiency, emphysema, prematurity, protein-losing disorders.
Ref range 2–4 g/L.
References in periodicals archive ?
Some early reference materials for A1AT were based on inhibition of trypsin preparations that varied markedly in enzyme activity and, therefore, in the assigned values for A1AT.
G], between-subject/ interindividual biological CV; CALIPER, Canadian Laboratory Initiative on Paediatric Reference Intervals; A1AT, [alpha]-1 antitrypsin; AGP, [alpha]-1 acid glycoprotein; C3, complement component 3; CRP, C-reactive protein; STfR, soluble transferrin receptor; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; GGT, [gamma] glutamyl transferase; HDL-C, HDL cholesterol; LDH, lactate dehydrogenase; [CV.
iPSCs that had undergone ZFN-mediated correction were differentiated in vitro into hepatocyte-like cells (the main cell type affected in the disease) that secreted active A1AT protein at levels comparable to normal adult hepatocytes.
Determinations of A1AT phenotype have typically been performed via inspection of isoelectric focusing gels.
We are pleased to collaborate with Intrexon on this exciting new endeavor for patients with A1AT deficiency," stated Gregory I.
The diagnosis of A1AT deficiency requires quantification of circulating A1AT and confirmation of the presence of A1AT disease alleles.
But we can overcome this challenge by a simple blood test that should be performed in all persons with family members having A1AT deficiency and in all persons who have no risk factors for early onset of COPD but are showing symptoms of disease.
The A1AT enzyme, a member of the serine protease-inhibitor family, is produced in the liver and diffuses into the lungs, where its main function is to protect the lungs against proteolytic damage from neutrophil elastase (4).
Thus, the measurement of the serum A1AT and the identification of the A1AT phenotype are clinically important.
A1AT deficiency is an autosomal codominant disorder with a prevalence of about 1:3000 in Caucasians [3].