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any of a group of enzymes that catalyze the hydrolysis of certain α-d-glucose residues from oligosaccharides and polysaccharides and yield free α-d-glucose. Called also maltase.
References in periodicals archive ?
Aspalathin content and inhibition of a-glucosidase served as initial screening parameters for selection of the solvent-based aspalathin-enriched extract, SB1, which was then used for subsequent in vitro cell culture and in vivo animal studies.
Long-term intravenous treatment of Pompe disease with recombinant human a-glucosidase from milk.
Determination of acid a-glucosidase protein: evaluation as a screening marker for Pompe disease and other lysosomal storage disorders.
In conclusion, we proved that this mushroom can be used as a therapy for diabetic mellitus in view of the fact that it has a component with a-glucosidase inhibitory activity, ganoderol B.
Human acid a-glucosidase from rabbit milk has therapeutic effect in mice with glycogen storage disease type II.
Retroviral transfer of acid a-glucosidase cDNA to enzyme-deficient myoblasts results in phenotypic spread of the genotypic correction by both secretion and fusion.
A traditional Chinese medical herb, Sangzhi (Ramulus mori), appears to have properties similar to those of a-glucosidase inhibitors.
TSX: MGI; OTC: MGIFF), a clinical-stage developer of drugs for infectious and degenerative diseases, has completed a Phase IIa monotherapy clinical study of celgosivir (MX-3253), an orally administered, first-in-class, a-glucosidase I inhibitor, in development for the treatment of chronic hepatitis C virus (HCV) infections.
MBI-3253, an a-glucosidase I inhibitor, has already demonstrated efficacy in a surrogate model of HCV infection and has been well tolerated in over 500 human subjects to date.
8 /PRNewswire/ -- Adding the a-glucosidase inhibitor, Precose(R) (acarbose tablets), to existing therapies for patients with Type 2 diabetes improves long-term blood glucose control, according to final results of the United Kingdom Prospective Diabetes Study (UKPDS).