FABP4

(redirected from A-FABP)

FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
And A-FABP are markers of intramuscular adipocytes in which IMF is mainly stored (Hocquette et al.
2009) found A-FABP gene expression and protein were significantly related with IMF content in ducks.
Associations of A-FABP and H-FABP markers with the content of intramuscular fat in Beijing-You chicken.
While some studies, however, have shown that elevations in pro-inflammatory and prothrombotic mediators such as interleukin (IL)-6, (19) IL-10, (20) adiponectin, (1) A-FABP, (21) and PAI-1 (22) play a role in metabolic-syndrome pathogenesis and/or detection, others have not.
Several independent studies have shown that targeted disruption of the A-FABP gene provides significant protection from both dietary and genetic obesity-associated insulin resistance, hyperglycemia, and fatty liver diseases and also leads to marked alleviation of inflammation and atherosclerosis associated with ApoE-deficient mice (3840).
6] Nonstandard abbreviations: T2DM, type 2 diabetes mellitus; IL, interleukin; TNF[alpha], tumor necrosis factor a; NGAL, neutrophil gelatinase--associated lipocalin; BMI, body mass index; PBS, phosphate-buffered saline; CRP; C-reactive protein; RBP4, retinol binding protein 4; HOMA-IR, homeostasis model assessment index for insulin resistance; hs-CRP; high-sensitivity C-reactive protein; A-FABP, adipocyte-fatty acid binding protein 4.
Many researchers have focused on the correlation between H-FABP, A-FABP and IMF content.
Functionally, both A-FABP and H-FABP are members of the FABP family that comprises a group of small cytosolic proteins which are involved in intracellular fatty acid transportation, cell growth and differentiation, cellular signaling, gene transcription, and protection of enzymes from the toxic effects of free fatty acids (Wang et al.
Since little work has been done on A-FABP and H-FABP gene expression in chickens, the objective of this research was to detect the relative expression of A-FABP and H-FABP genes in different tissues of chickens using FQ-RT-PCR, and further analyze the correlation between transcription level of A-FABP and H-FABP genes and IMF content.
A-FABP is a predominant cytosolic protein of mature adipocytes, accounting for ~6% of total cellular proteins.
A-FABP is present in macrophages (9,15), which have striking similarities to adipocytes in biology and function (16).
Furthermore, it was also reported there was a significant difference (about 1%) among genotypes of A-FABP in Duroc pigs.