FABP4

(redirected from A-FABP)

FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
The A-FABP and LEP genes were more active in fat tissue with moderately lower levels also in muscle, contributing to intramuscular fat accumulation.
A-FABP plasma levels have been associated with the number of adipocytes and intramuscular fat content (IMF) in pigs (Damon et al.
And A-FABP are markers of intramuscular adipocytes in which IMF is mainly stored (Hocquette et al.
2009) found A-FABP gene expression and protein were significantly related with IMF content in ducks.
H-FABP is the dominant FABP type in skeletal muscles, but A-FABP is also
While some studies, however, have shown that elevations in pro-inflammatory and prothrombotic mediators such as interleukin (IL)-6, (19) IL-10, (20) adiponectin, (1) A-FABP, (21) and PAI-1 (22) play a role in metabolic-syndrome pathogenesis and/or detection, others have not.
Several independent studies have shown that targeted disruption of the A-FABP gene provides significant protection from both dietary and genetic obesity-associated insulin resistance, hyperglycemia, and fatty liver diseases and also leads to marked alleviation of inflammation and atherosclerosis associated with ApoE-deficient mice (3840).
6] Nonstandard abbreviations: T2DM, type 2 diabetes mellitus; IL, interleukin; TNF[alpha], tumor necrosis factor a; NGAL, neutrophil gelatinase--associated lipocalin; BMI, body mass index; PBS, phosphate-buffered saline; CRP; C-reactive protein; RBP4, retinol binding protein 4; HOMA-IR, homeostasis model assessment index for insulin resistance; hs-CRP; high-sensitivity C-reactive protein; A-FABP, adipocyte-fatty acid binding protein 4.
Especificidad por acidos grasos del alergeno Bio 113 LIGANDO Bio 113 A-FABP L-FABP ABA-1 A.
Many researchers have focused on the correlation between H-FABP, A-FABP and IMF content.
A-FABP is a predominant cytosolic protein of mature adipocytes, accounting for ~6% of total cellular proteins.
Furthermore, it was also reported there was a significant difference (about 1%) among genotypes of A-FABP in Duroc pigs.