TNFSF13

(redirected from A proliferation-inducing ligand)

TNFSF13

A gene on chromosome 17p13.1 that encodes a cytokine of the tumour necrosis factor family, which binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. It is highly expressed in cancers of the colon, thyoid and lymphoid tissues; it may regulate tumour cell growth and be involved in macrophage-mediated immunity. It is popularly known as APRIL.
References in periodicals archive ?
The present Competitive Intelligence Report about BlyS, BAFF & APRIL Targeted Therapy provides a competitor evaluation in the field of molecules targeting B-lymphocyte stimulator (BlyS), B-cell activating factor of the TNF family (BAFF) and of a proliferation-inducing ligand (APRIL) as of February 2010.
The report includes a compilation of currently active projects in research and development of antibodies and antibody-based molecules targeting B-lymphocyte stimulator (BlyS), B-cell activating factor of the TNF family (BAFF) and of a proliferation-inducing ligand (APRIL) for treatment of inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis and multiple sclerosis.