ADAMTSbc12

(redirected from A Disintegrin and Metalloproteinase with Thrombospondin Motifs 12)

ADAMTSbc12

An ADAMTSs family enzyme encoded by ADAMTS12 on chromosome 5q35, which is structurally similar to ADAMTS7. ADAMTS12 is expressed almost exclusively in the fetus, where it may play a role in lung development. It is expressed in gastric carcinomas but not in adjacent normal tissue. ADAMTS12 cleaves alpha-2 macroglobulin and aggregan, is involved in cell adhesion and has anti-tumourigenic properties.
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