ADAM1bja19

(redirected from A Disintegrin And Metalloproteinase Domain 19)

ADAM1bja19

An ADAMs family protein encoded by ADAM19 on chromosome 5q33.3, which is involved in various physiologic and pathological processes, including cell migration, cell adhesion, cell-cell and cell-matrix interactions, signal transduction, and organogenesis.
Normal activity ADAM19 is involved in proteolytic processing of neuregulins involved in neurogenesis and synaptogenesis, suggesting glial cell regulation. ADAM19 cleaves alpha-2 macroglobulin, and may have a role in bone formation. ADAM19 is highly expressed in dorsal root ganglia and ventral horns of the spinal cord, where peripheral neuronal cell lines differentiate. Like ADAM17, but to a lesser degree, ADAM19, can function as a TNF-alpha sheddase, releasing TNF-alpha from a membrane-bound precursor. ADAM19 is also involved in cardiac morphogenesis, giving rise to the membranous septa and valves. Knock-out mice lacking ADAM19 have ventricular septal defects and underdeveloped valves; most die shortly after birth, which may be due to the loss of proteolytic regulation of ErbB ligands by ADAM19.
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