RPS6KA5

(redirected from 90 kDa ribosomal protein S6 kinase 5)

RPS6KA5

A gene on chromosome 14q31-q32.1 that encodes a p90 ribosomal S6  serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factors RELA, STAT3 and ETV1/ER81. RPS6KA5 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.