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9-cis-retinoic acid

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9-cis-retinoic acid
AIDS A retinoid that may have some efficacy in topical management of KS Adverse effects Skin irritation, photosensitivity. See AIDSALRT 1057.


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Bollag and Ott had originally shown the effectiveness of 9-cis-retinoic acid as a treatment [1], and results of an extensive trial were published in 2004 [2].
All-trans retinoic acid (RA) and 9-cis-retinoic acid (9cRA) are activators of Retinoic Acid Receptors (RARs).
Meanwhile, 9-cis-retinoic acid (9-cis-RA) can bind another series of retinoid receptors, termed retinoid X receptors (RXR), and initiate transcription of RXR responsive genes in a ligand-dependent fashion (discussed by Rohde et al.
 
 
 
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