matrix metalloproteinase 2

(redirected from 72-kD collagenase)

matrix metalloproteinase 2

A 62-kD tissue enzyme encoded on chromosome 16q13-q21 that degrades collagens and other matrix proteins, and which may be linked to cancer.

Cytokine inducers
Activin, CD40L, EGF, endothelin-1, FGF-b, FGF-3, G-CSF, GM-CSF, HGF, IFN-α, IFN-γ, IGF-1, IL-1α, IL-1β, IL-3, IL-6, sIL-6 Rα, IL-8, IL-18, LIF, M-CSF, MIF, oncostatin M, PDGF, SCF, TGF-α, TGF-β1, TNF-α, VEGF.
 
Substrates
3 α-chains of native Collagens I, IV, V, VII, X, XI, and XIV; gelatin, elastin, fibronectin, laminin-1, laminin-5, galectin, aggrecan, decorin, hyaluronidase-treated versican, proteoglycan link protein, osteonectin, MBP, GST-TNF/TNF peptide, IL-1β, serum amyloid A, APP695, α1-AT, prolysyl oxidase fusion protein, IGF-BP5, IGF-BP5, FGF R1, MMP-1, MMP-9, MMP-13.