7-dehydrocholesterol


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7-de·hy·dro·cho·les·ter·ol

(dē-hī'drō-kō-les'tĕr-ol),
A zoosterol in skin and other animal tissues that on activation by ultraviolet light becomes antirachitic and is then referred to as cholecalciferol (vitamin D3).
Synonym(s): provitamin D3

7-dehydrocholesterol

/7-de·hy·dro·cho·les·ter·ol/ (de-hi″dro-kŏ-les´ter-ol) a sterol present in skin which, on ultraviolet irradiation, produces vitamin D.
activated 7-dehydrocholesterol  cholecalciferol.

7-dehydrocholesterol

(dē-hī″drō-kŏ-les′tĕ-rol″)
A steroid precursor of vitamin D that converts to the vitamin when skin is exposed to sunlight.
References in periodicals archive ?
We tested the GC IDMS method and the LC IDMS method for the possible interference of 7-dehydrocholesterol, 5[alpha]-cholest-7-en-3[beta]-ol (lathosterol), lanosterol, [beta]-sitoserol, ergosterol, cholest-4,6-dien-3-one, coprostan3-ol, 25-hydroxycholesterol, cholesterol-5[alpha],6[alpha]-epoxide, 4-cholesten-3-one, 5-cholesten-3-one, and dihydrocholesterol.
Patients have decreased concentrations of cholesterol in plasma and increased concentrations of the precursor 7-dehydrocholesterol (cholesta-5,7-dien-3[beta]-ol; 7-DHC) and its isomer 8-dehydrocholesterol (cholesta-5,8-dien-3[beta]-ol; 8-DHC) in plasma, erythrocytes, cultured skin fibroblasts, amniotic fluid, and various tissues [4-8]--findings that suggest a block in reduction of the C-7 double bond [4, 5].
3] is formed in the skin from its precursor 7-dehydrocholesterol after ultraviolet irradiation or is absorbed from the diet (2).
3]) is either ingested in the diet or synthesized in the skin from 7-dehydrocholesterol through exposure to sunlight (60).
Animals synthesize 7-dehydrocholesterol, the immediate precursor of cholesterol; absorption of ultraviolet B radiation (290-315 nm) leads to a rearrangement of the 5-7-dime in the B ring of 7-dehydrocholesterol, causing ring breakage to form previtamin [D.
3]) produced in skin via a photochemical reaction with 7-dehydrocholesterol (1); and ergocalciferol (vitamin [D.
SLOS is caused by a deficiency of the enzyme 7-dehydrocholesterol reductase (EC 1.
Prenatal diagnosis of Smith-Lemli-Opitz syndrome is possible by measurement of 7-dehydrocholesterol in amniotic fluid.
Campesterol, sitosterol, stigmasterol, desmosterol, lathosterol, 7-dehydrocholesterol, and butylated hydroxytoluene were obtained from Sigma-Aldrich Chemie.
Vitamin D3 is made through the ultraviolet irradiation of 7-dehydrocholesterol from lanolin.
Ultraviolet activation of 7-dehydrocholesterol in the epidermis is the predominant source of cholecalciferol or vitamin [D.