thioguanine

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thioguanine

 [thi″o-gwah´nēn]
a guanine analogue in which sulfur replaces the oxygen atom of guanine; used as an antineoplastic agent almost exclusively in the treatment of acute myelogenous leukemia and acute lymphoblastic leukemia. Called also 6-thioguanine and 6-TG.

thioguanine

/thio·gua·nine/ (-gwah´nēn) an antineoplastic derived from mercaptopurine; used in the treatment of acute myelogenous leukemia.

thioguanine

[thī′ōgwä′nēn]
a purine analog antagonist, an antineoplastic that acts as an antimetabolite.
indications It is prescribed in the treatment of a variety of malignant neoplastic diseases, especially acute and chronic myelogenous leukemias.
contraindications Known hypersensitivity or resistance to this drug prohibits its use. It is not given during pregnancy.
adverse effects Among the most serious adverse effects are bone marrow depression, GI distress, and stomatitis.

thioguanine

Lanvis® Oncology An antimitotic purine analogue, used against AML. See Purine.

thioguanine

Tioguanine, a drug used in the treatment of acute myeloblastic leukaemia. A brand name is Lanvis.

thioguanine

an antineoplastic (2-aminopurine-6-thiol) used in the treatment of leukemia.
References in periodicals archive ?
Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.
Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans.
We chose the basic assay (2) for three reasons: (a) this procedure has been routinely used in our laboratory for many years; (b) there is good comparison between the 6-thioguanine nucleotide (6-TGN) concentrations measured with both procedures (unpublished own observations); and (c) 6-TGNs are considered the active thiopurine metabolites, whereas the role of 6-methyl-mercaptopurine for therapeutic drug monitoring is still a matter of debate (except for compliance).
Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy.
Thiopurine Smethyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate.
If patients with a homozygous deficiency of TPMT are given thiopurine derivatives at a standard therapeutic oral dosage, 6-thioguanine nucleotides will accumulate, usually within 4-6 weeks, to toxic concentrations.
High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantification of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and methylmercaptopurine metabolites in a single sample.
3) This anabolic route leading to 6-thioguanine nucleotides (6-TGNs) is in competition in red blood cells (RBCs) with methylation of 6-TIMP into methyl 6-TIMP (Me6-TEMP) via thiopurine S-methyltransferase (TPMT), a cytosolic, S-adenosyl methionine-dependent enzyme.
Differential chromatid damage induced by 6-thioguanine in CHO cells.
6-MP is further converted in the liver and gut to 6-thioguanine nucleotides, the pharmacologically active metabolites, by several enzymes, including hypoxanthine guanine phosphoribosyltransferase.