reductase

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reductase

 [re-duk´tās]
an enzyme that catalyzes a chemical reduction.
5α-reductase an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone.

re·duc·tase

(rē-dŭk'tās),
An enzyme that catalyzes a reduction; because all enzymes catalyze reactions in either direction, any reductase can, under the proper conditions, behave as an oxidase and vice versa, hence the term oxidoreductase. For individual reductases, see the specific names.
Synonym(s): reducing enzyme

reductase

/re·duc·tase/ (-tās) a term used in the names of some of the oxidoreductases, usually specifically those catalyzing reactions important solely for reduction of a metabolite.
5α-reductase  an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone; enzyme deficiency leads to a form of male pseudohermaphroditism.

reductase

(rĭ-dŭk′tās′, -tāz′)
n.
Any of various enzymes that catalyze the reduction of an organic compound.

reductase

A generic term for any enzyme that catalyses a chemical reduction reaction.

re·duc·tase

(rĕ-dŭk'tās)
An enzyme that catalyzes a reduction; because all enzymes catalyze reactions in either direction, any reductase can, under the proper conditions, behave as an oxidase and vice versa; hence the term oxidoreductase.

reductase

an ENZYME that catalyses the REDUCTION of a compound.

reductase

an enzyme that catalyzes a chemical reduction.

5α-reductase
an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone.
References in periodicals archive ?
New mutations, hotspots, and founder effects in Brazilian patients with steroid 5alpha-reductase deficiency type 2.
Molecular analysis of the SRD5A2 in 46,XY subjects with incomplete virilization: the P212R substitution of the steroid 5alpha-reductase 2 may constitute an ancestral founder mutation in Mexican patients.
Molecular analysis of 5alpha-reductase type 2 gene in eight unrelated Egyptian children with suspected 5alpha-reductase deficiency: prevalence of the G34R mutation.
Early diagnosis of 5alpha-reductase deficiency in newborns.
A novel frameshift mutation in the 5alpha-reductase type 2 gene in Korean sisters with male pseudohermaphroditism.
Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor dutasteride.
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
The nicotinamide adenine dinculeotide phosphate (NADPH)-dependent membrane protein 5alpha-reductase irreversibly catalyses the conversion of testosterone to the most potent androgen, 5alpha-dihydrotestosterone (DHT).
The aim of the present study was to determine the in vitro potency of a novel saw palmetto ethanol extract (SPET-085) an inhibitor of the 5alpha-reductase isoenzyme type II, in a cell-free test system.
SPET-085 concentration-dependently inhibited 5alpha-reductase type II in vitro.
Drug Insight: 5alpha-reductase inhibitors for the treatment of benign prostatic hyperplasia.
Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor.