Primary prevention of PCa has focused on chemoprevention, vitamin supplements (selenium, Vitamin E, and Vitamin C), and 5a-reductase inhibitors
(finasteride and dutasteride).
The Risks and Benefits of 5a-Reductase Inhibitors
for Prostate-Cancer Prevention.
They compared 2312 Icelandic men who underwent medical or surgical management for BPH (including treatment with 5a-reductase inhibitors
, which are known to lower the PSA concentration) vs 33 779 presumed-healthy Icelandic men.
A second category of medicines includes what are termed the 5a-reductase inhibitors
, including Proscar and Avodart.
Use of 5a-reductase inhibitors
for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline.
3 5a-Reductase Inhibitors
- The Finasteride Story (J.
Because of the ability of 5a-reductase inhibitors
to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride.
The changes described above are expected pharmacological effects of drugs belonging to the class of 5a-reductase inhibitors
and are similar to those reported in male infants with a genetic deficiency of 5a-reductase.