DIO1

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DIO1

A gene on chromosome 1p33-p32 that encodes a thiol-requiring propylthiouracil-sensitive oxidoreductase. DIO1 activates thyroid hormone by converting the prohormone thyroxine (T4) by outer-ring deiodination to bioactive 3,3’,5-triiodothyronine (T3). It also degrades T3 and T4 by inner-ring deiodination.
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For more information contact: Mandy Davies, Victorian Festival Office, Old Town Hall, Temple Street, Llandrindod Wells, LD1 5DI.