MTR(redirected from 5-methyltetrahydrofolate-homocysteine methyltransferase 1)
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MTRA gene on chromosome 1q43 that encodes an enzyme which transfers a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It then remethylates the cofactor using methyltetrahydrofolate.
Defects in MTRR cause methylcobalamin deficiency type E and folate-sensitive neural tube defects.