ALOX5

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ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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References in periodicals archive ?
This minority of asthmatics likely represents the fraction of asthmatics that would improve significantly from anti-leukotriene drugs, including a 5-lipoxygenase inhibitor or leukotriene receptor antagonist.
For balanced selective inhibition of COX-2, combined with the inhibition of TNF-alpha and IL-1 beta, to work, it is essential to block the additional inflammatory pathway, 5-lipoxygenase (5-LOX), which produces pro-inflammatory leukotrienes.
Among the topics are developing palladium-catalyzed arylations of carbonyl-activated carbon-hydrogen bonds, process development and scale-up of a novel antibiotic, copper-catalyzed carbon-nitrogen coupling on a large scale, transition metal-catalyzed coupling reactions in the synthesis of taranabant, developing Migita couplings for the manufacture of a 5-lipoxygenase inhibitor, and applying the hydrophobic effect to transition metal-catalyzed couplings in water at room temperature.
18) One way that the body rids itself of excess arachidonic acid is by provoking a dangerous metabolizing pathway through 5-lipoxygenase (5-LOX).
Washington, May 1 ( ANI ): Scientists believe that a specific enzyme, called 5-lipoxygenase, plays a key role in cell death induced by microgravity environments, and suggested that inhibiting this enzyme will likely help prevent or lessen the severity of immune problems in astronauts caused by spaceflight.
Gene expression profiling using Affymetrix microarray of normal and OA cartilage showed the presence of various mRNA representing proteins associated with eicosanoids pathway enzymes, such as COX, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase pathways (Amin and colleageus unpublished data).
inhibitors of 5-lipoxygenase enzyme and block Human Leukocyte Elastase (HLE) activity; a unique dual inhibition.
Leukotriene modifiers are categorized as either leukotriene receptor antagonists (LTRAs) or 5-lipoxygenase pathway inhibitors.
Boswellic acids have been shown to inhibit the 5-lipoxygenase enzyme in the metabolic pathway leading to inflammotary leuykotrienes.
It inhibits pro-inflammatory mediators in the body, specifically leukotrienes via inhibition of 5-lipoxygenase, the key enzyme of leukotriene synthesis, is the scientifically proved mechanism for its anti-inflammatory/anti-arthritic activity.
Topics addressed include the use of vitamins E and C for prevention of cardiovascular disease; current data from both basic and clinical research on the role of vitamin E in cardiovascular disease and on vascular health; modulation of cellular signaling and gene expression by vitamin E; new findings on the role of vitamin E in cellular antioxidant defense; vitamin E, 5-lipoxygenase and kidney disease; and a possible ability of vitamin E to improve immune unresponsiveness induced by chronic viral infections.
Magnesium's functions include effects on platelet aggregation, vasospasm, and release of inflammatory mediators, while feverfew inhibits prostaglandin synthetase, 5-lipoxygenase, and cyclooxygenase in leukocytes and serotonin secretion in platelets and polymorphonuclear leukocytes.

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