It has been shown to inhibit the pro-inflammatory enzyme 5-lipooxygenase
They are reported to inhibit both cyclooxygenase (COX) and 5-lipooxygenase
(LOX) pathways of arachidonic acid metabolism.
Selectivity of neutrophil 5-lipooxygenase
and cyclo-oxygenase inhibitor by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids.
Alternatively, Mk may act inhibiting the synthesis and/or the effect of LTB4 as recently suggested by the demonstration that antagonist of LT receptors are alosteric inhibitors of the 5-lipooxygenase
In addition, prostaglandins synthesis by NSAIDs is also associated with an increased production of leukotrienes by 5-Lipooxygenase
Polymorphisms in the gene for 5-lipooxygenase
activating protein were recently reported to be associated with stroke risk (17,18), but because we began our study before this genetic variant was identified, analysis of this SNP is not included.
There are other mechanisms involved in the evolution of a prostate tumor such as 5-lipooxygenase
(5-LOX) (53-55) and cyclooxygenase-2 (COX-2) (56) that can be markedly improved by dietary changes, along with curcumin, (57), (58) fish oil,59-61 boswellia,62 aspirin,63 Zyflamend[R],64-68 and prescription COX-2 inhibitors like Celebrex[R].
In fact, the inhibitory effects of the essential oil of Nigella sativa and thymoquinone have been shown on both cyclooxygenase and 5-lipooxygenase
pathways of arachidonic acid metabolism and also on membrane lipid peroxidation (Houghton et al.
At least one study has linked the protective effects of quinacrine to inhibition of 5-lipooxygenase
and reduction of neurotoxicity in cells inoculated with PrP106-126 (70).
Leukotriene B4 (LTB4): A cytokine synthesized from the pro-inflammatory omega-6 arachidonic acid and 5-lipooxygenase
4] (by inhibiting cyclooxygenase and 5-lipooxygenase
, respectively), and membrane lipid peroxidation (Houghton et al.
A plethora of research documents the role of chronic inflammatory mediators such as 5-lipooxygenase
(5-LOX) and tumor necrosis factor-alpha (TNF-[alpha]) in the manifestation and progression of prostate and other cancers.