5-lipooxygenase

5-lipooxygenase

(li-pō-oks'ē-jen-ās),
An enzyme that catalyzes the conversion of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid and then to leukotriene A4.
References in periodicals archive ?
Studies on the mechanism of anti-inflammatory and anti-ulcer activity of Pluchea indica-probable involvement of 5-lipooxygenase pathway.
Selectivity of neutrophil 5-lipooxygenase and cyclooxygenase inhibition by an anti-inflammatory glycoside and related aglycone flavonoids.
It may be mentioned here that the antiinflammatory activity of Phillyrea latifolia L is found to be due to ursolic acid, which inhibit cyclooxygenase and 5-lipooxygenase enzymes of arachidonate cascade (Diaz et al.
Their anti-inflammatory effects have been attributed to the inhibition of different events of an inflammatory reaction, such as histamine release, cyclooxygenase-2, and 5-lipooxygenase pathways of arachidonic acid metabolism, elastase activity, complement activity and nitric oxide production (Kapil and Sharma, 1995; Liu, 1995; Ringbom et al.
There are other mechanisms involved in the evolution of a prostate tumor such as 5-lipooxygenase (5-LOX) (53-55) and cyclooxygenase-2 (COX-2) (56) that can be markedly improved by dietary changes, along with curcumin, (57), (58) fish oil,59-61 boswellia,62 aspirin,63 Zyflamend[R],64-68 and prescription COX-2 inhibitors like Celebrex[R].
Selectivity of neutrophil 5-lipooxygenase and cyclo-oxygenase inhibitor by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids.
An article detailing the study, titled "Pro-Inflammatory Enzymes, Cyclooxygenase 1, Cyclooxygenase 2, and 5-Lipooxygenase, Inhibited by Stabilized Rice Bran Extracts," has been published in the June 2009 issue of the peer-review Journal of Medicinal Food.
In addition, prostaglandins synthesis by NSAIDs is also associated with an increased production of leukotrienes by 5-Lipooxygenase.
Polymorphisms in the gene for 5-lipooxygenase activating protein were recently reported to be associated with stroke risk (17,18), but because we began our study before this genetic variant was identified, analysis of this SNP is not included.
In fact, the inhibitory effects of the essential oil of Nigella sativa and thymoquinone have been shown on both cyclooxygenase and 5-lipooxygenase pathways of arachidonic acid metabolism and also on membrane lipid peroxidation (Houghton et al.
Leukotriene B4 (LTB4): A cytokine synthesized from the pro-inflammatory omega-6 arachidonic acid and 5-lipooxygenase.
At least one study has linked the protective effects of quinacrine to inhibition of 5-lipooxygenase and reduction of neurotoxicity in cells inoculated with PrP106-126 (70).

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