5-alpha reductase

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5-alpha reductase

(al'fa re-duk'tās),
Intracellular enzyme that converts testosterone to 5-alpha dihydrotestosterone (DHT). Two distinct isoforms are known in humans and laboratory animals.

5-alpha reductase

An enzyme that converts testosterone to dihydrotestosterone.
See also: reductase
References in periodicals archive ?
ALA at a physiological concentration has been reported to inhibit the enzyme 5-alpha-reductase in vitro.
Protodioscin acts by stimulating the enzyme 5-alpha-reductase, which plays a role in the conversion of testosterone into dihydrotestosterone (Viktorof et al.
4] The mainstay of medical treatments includes alpha-blockers, 5-alpha-reductase inhibitors (5-ARIs), or a combination of the two.
First-line therapies indude alpha-1 adrenergic receptor antagonists (alpha-blockers) and 5-alpha-reductase inhibitors (5-AR1s).
Exclusion criteria also included: consumption of food rich in soy isoflavonoids, dietary supplements of any kind, medication with possible effects on prostate health such as antibiotics, anti-inflammatory drugs, alpha-1 -adrenoreceptor antagonist and 5-alpha-reductase inhibitors.
When testosterone interacts with the enzyme 5-alpha-reductase, DHT is created in the scalp.
A new mutation of 5-alpha-reductase type 2 (A62E) in a large Egyptian kindred.
Cancer chemopreventive approaches may include 5-alpha-reductase inhibitors, histone deacetylase inhibitors, antioxidans, non-steroidal anti-inflammatory drugs, cholesterol-lowering statins, vitamin D analogues.
This proprietary-active complex is believed to act on recessing hair by limiting hormonal influence through inhibition of 5-alpha-reductase activity, preventing aggravation of hair loss due to micro-inflammation.
She explained that there are several genetic or hormonal disorders (Testicular feminisation syndrome, hermaphroditism, Klinefelter syndrome, 5-Alpha-reductase deficiency) that would lead to uncertainty about a person's gender.
Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5-alpha-reductase inhibitor dutasteride.
The advanced stage is treated with medicines (plant-based preparations, alpha-1-receptor blockers or 5-alpha-reductase inhibitors); thereafter, surgery is required.

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