5-alpha reductase


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5-alpha reductase

(al'fa re-duk'tās),
Intracellular enzyme that converts testosterone to 5-alpha dihydrotestosterone (DHT). Two distinct isoforms are known in humans and laboratory animals.

5-alpha reductase

An enzyme that converts testosterone to dihydrotestosterone.
See also: reductase
References in periodicals archive ?
There are much safer ways to create mechanisms of action for 5-alpha reductase inhibition and for aromatase inhibition at the same time.
Physicians using 5-alpha reductase inhibitors should take into account the PSA-lowering effect of these agents by doubling the PSA lab value.
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibennzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose dependent increase of mRNA levels of 5-alpha reductase type 2 in contrast to decrease of androgen receptor in pubertal ventral prostate.
Jean Wilson's discovery of the role of the enzyme 5-alpha reductase in BPH.
Screenings showed that oleanoic acid (OA) derived from olive tree leaves inhibits 5-alpha reductase type I activity, which influences testosterone levels and hyperseborrhea.
The treatment works by stopping the action of an enzyme called 5-alpha reductase which converts male testosterone into DHT, a hormone that triggers the hair loss process in men.
The mechanism of action of finasteride is to inhibit the steroid 5-alpha reductase, which is an intracellular enzyme that converts testosterone into the potent androgen 5-alpha dihydrotestosterone (DHT).
Made primarily in the prostate, this enzyme, 5-alpha reductase type II, converts testosterone to dihydrotestosterone (DHT).
Drugs such as botulinum toxins, retinoids, acid peels, 5-alpha reductase and lipase inhibitors associated with cutaneous ageing, photodamage, pigmentation defects, alopecia, and the lipodermal disorders of obesity and gynoid lipodystrophy are critically discussed to provide a detailed analysis of the high-growth market sector estimated at US$1.
Medications known as 5-alpha reductase inhibitors (5-ARIs) do not increase the likelihood of suicide, but they are associated with a greater risk of depression and self-harm, a recent study suggests.
Throughout Chris Meletis's clinical career working from the foundational base of the neuroendocrine theory of aging, he has postulated a concept that he terms the NeSID (neuroendocrine stress-induced dysfunction) effect, which incorporates the role of stress on both the 5-alpha reductase and COMT pathways.
I suggest that we can start with compounds, especially dietary agents that could inhibit 5-alpha reductase.

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