There is a need for randomized controlled trials to analyze the efficacy and side-effects of combination therapy with PDE-5 inhibitors and 5-alpha reductase
Physicians using 5-alpha reductase
inhibitors should take into account the PSA-lowering effect of these agents by doubling the PSA lab value.
Ross' group has now taken a close look at the gene encoding 5-alpha reductase
In patients with localized prostate cancer undergoing AS, how does supplementation with 5-alpha reductase
inhibitors (5ARIs) (e.
5 Alpha Avocuta is shown to significantly inhibit 5-alpha reductase
activity, and help prevent itching, redness and desquamation.
Reasons for the current stagnation of progress include failure of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) to show preventive activity of selenium and vitamin E; the failure of a high-risk phase III study to show preventive activity of selenized yeast; the refusal of the Food and Drug Administration to approve finasteride for prostate cancer prevention; and uncertainty regarding the long-term effects of treatment with 5-alpha reductase
inhibitors, according to Dr.
A review of several published reports attribute the higher Gleason scores observed in the groups taking the 5-alpha reductase
inhibitors (Avodart[R] or Proscar[R]) to the fact that it was easier to find high-grade cancers in the shrunken glands of men taking these drugs compared to the much larger glands of men in the placebo group.
comparison of Finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase
in healthy male volunteers.
Whilst some symptoms of BPH are successfully addressed by the standard BPH therapies of alpha blockers and 5-alpha reductase
inhibitors, nocturia remains inadequately treated.
The use of 5-alpha reductase
inhibitors in AS is unclear at this time, but they may have a role.
The easiest way to reduce PSA is to inhibit the enzyme 5-alpha reductase
, which transforms testosterone into the more androgenic dihydrotestosterone (DHT).
Methods to achieve these goals include lowering estrogens and androgens by stimulating SHBG and inhibiting 5-alpha reductase
to inhibit conversion of testosterone to DHT, and modifying insulin resistance and lowering oversecretion of insulin.