ALOX5

(redirected from 5-LOX)

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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By inhibiting both COX-2 and 5-LOX pathways, licofelone decreased the production of inflammatory chemicals like leukotrienes and prostaglandins (Gracia-Alvaro, 2004; Khurdayan and Matito, 2007).
Based on different pathways involved in oxylipin biosynthesis, metabolites were classified by the main biosynthetic pathways COX, CYP, 5-LOX, and 12/15LOX (Figure 1; see also Table S4) (Zivkovic et al.
Boswellia serrata strongly inhibits 5-LOX pathway, another inflammatory pathway causing brain tumor growth and brain edema, in patients with glioblastoma.
Moreover, the plant extract blocked leukotriene LTB4 release, the major end product of the 5-LOX pathway from PBMC.
In each of these conditions, inflammation of the bowel lining is kept alive largely through excessive production of inflammatory mediators called leukotrienes, which are produced by the 5-LOX enzyme.
Researchers at the University of Teramo, the European Centre for Brain Research and the Santa Lucia Foundation have discovered that a particular enzyme, called 5-LOX, becomes more active in weightlessness.
In addition to these actions, it has also been reported to possess anti-inflammatory properties, via its inhibitory action on 5-lipoxygenase (5-LOX) in vitro, which in turn blocks the synthesis of 5-LOX products, thus inhibiting leukotriene synthesis.
This compound is an arachidonic acid substrate analogue that inhibits both COX and 5-LOX.
Boswellia serrata, Herb Inhibits TNF-a and IL-1 and resin inhibits 5-LOX and LTB-4.
It is well established that 5-LOX products stimulate prostate cancer cell proliferation via several well-defined mechanisms.

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