ALOX5

(redirected from 5-LOX)

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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References in periodicals archive ?
In a mouse study, an increase in 5-LOX resulted in a corresponding increase in vascular endothelial growth factor, a key growth factor that tumor cells use to stimulate new blood vessel formation (angiogenesis) into the tumor.
Conclusion: ITE, which has been reported inhibiting COX-2 and 5-LOX, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL-4 and IL-5, and RANTES.
It has been previously determined that mixtures of baicalin and catechin possessed significant COX-1, COX-2, and 5-LOX inhibitory activity.
Raffaella Canali of the National Research Institute on Food and Nutrition in Rome, Italy, found that Pycnogenol inhibits the generation of COX-2 and 5-LOX, two naturally occurring enzymes associated with a host of inflammatory conditions.
In each of these conditions, inflammation of the bowel lining is kept alive largely through excessive production of inflammatory mediators called leukotrienes, which are produced by the 5-LOX enzyme.
Researchers also report that an herbal inhibitor of 5-LOX has proved to be valuable in the treatment of arthritis.
Researchers at the University of Teramo, the European Centre for Brain Research and the Santa Lucia Foundation have discovered that a particular enzyme, called 5-LOX, becomes more active in weightlessness.
This compound is an arachidonic acid substrate analogue that inhibits both COX and 5-LOX.
The expressions of COX-2 and 5-LOX in PBMC were also inhibited by administration of EVNS.
It is well established that 5-LOX products stimulate prostate cancer cell proliferation via several well-defined mechanisms.

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