patent covering a number of 5-LO
inhibitor compounds, including CMI-977, and their use in treating inflammatory and other disorders.
ZYFLO is the only 5-LO
inhibitor approved for marketing by the U.
In the second poster, "A Role for the 5-LO
Pathway in Allergen-Induced Airway Infiltration of Eosinophils and Neutrophils in a Murine Model of Asthma," lead author Lyn Libertine of Critical Therapeutics and her colleagues show that ZYFLO plays a key role in inhibiting the migration, aggregation and adhesion of eosinophils and neutrophils in response to leukotrienes, which play an important role in inflammation.
Taken orally, zileuton inhibits the 5-LO
enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.
The results demonstrated that ECF administration exerted a powerful anti-inflammatory activity as evidenced by the reduction in the pro-inflammatory markers; IL-1[beta], TNF-[alpha], 5-LO
NSO produced a concentration dependent inhibition of 5-LO
products and 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) production with half maximal effects (IC(50)) at 25+/-1 micro g/ml, respectively 24+/-1 micro g/ml.
protein constitutively expressed by OA chondrocytes could be further induced by IL-1[beta] treatment.
VIA-2291 is designed to be a selective and reversible inhibitor of 5-LO
, a key enzyme in the biosynthesis of leukotrienes, that are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis.
In contrast, there is limited information on the ability of other tocopherol isomers to inhibit 5-LO
Inflamol(tm), developed by scientists in Colorado, works by effectively inhibiting all three enzymes that trigger inflammation and pain in the body (COX-2, 5-LO
and partially COX-1), without side effects, setting it aside from other pain relief products on the market.
Cambridge, MA) has patented nucleic acid molecules having a nucleotide sequence of an allelic variant of a 5-LO
The enzyme 5-LO
normally plays a key role in initiating the body's breakdown of arachidonic acid -- a fatty acid present in all cells -- into leukotrienes, potent compounds that stimulate inflammation and allergic responses.