Close relationships have been observed between 5-HT
and GABA in vertebrates, such as the rabbit (Osborne & Beaton 1986) and the cat (Wassle & Chun 1988), with double-labeling studies demonstrating the coexistence of these 2 neurotransmitters in amacrine cells of the retina.
It is well known that at CNS level, tianeptine triggers the absolute disappearance of 5-HT
from synaptic clefts.
Immortalized raphe cells secreting both 5-HT
and brain-derived neurotrophic factor reduce nociception and improve locomotion when implanted in the subarachnoid space after thoracic hemisection .
Morphological study of 5-HT
neurons and astroglial cells on brain of adult rats perinatal or chronically exposed to 2,4-dichlorophenoxy acetic acid.
Since subjects with the main confounding factors were excluded from the study, and the subjects investigated were matched by sex, age, and working life, the data suggest the possibility that occupational exposure to urban pollutants in traffic police can have an influence on 5-HT
turnover and therefore on 5-HIAA(U)]excretion.
Liquid chromatography with electrochemical detection provides the highest sensitivity for the determination of human plasma 5-HT
Because intake of the amino acid tryptophan is directly related to 5-HT
synthesis, research also has examined the effects of diets offering little tryptophan.
We have robust evidence that there is something wrong with the 5-HT
system in depressed patients," says de Montigny.
Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT
) which plays a role in thermoregulation, I hypothesize that 5-HT
is a crucial component of my circuit.
b) Valerian has demonstrated anti-inflammatory actions, stimulatory effects on 5-HT
and Ach receptors, and reduction of sleep-disturbance
These results suggest that limonene may inhibit stimulant-induced behavioral changes via regulating dopamine levels and 5-HT
Moreover, there is evidence that abnormalities of 5-HT
functions are related to the pathophysiology of diverse neurological conditions including Parkinson's disease, tardive dyskinesia, akathisia, dystonia, Huntington's disease, familial tremor, restless legs syndrome, myoclonus, Gilles de la Tourette's syndrome, multiple sclerosis, sleep disorders, and dementia.