The double-blind TELECAST study enrolled 76 patients with or without concomitant SSA therapy provided they qualified based on at least one sign/symptom of carcinoid syndrome, such as at least two episodes of flushing per day, elevated urinary 5-HIAA
at baseline, or nausea present on at least one out of five days at baseline.
A subsequent serum chromogranin A was elevated at 52 ng/ml (reference normal <34 ng/ml) and a 24-hour urine 5-HIAA
was elevated at 15 mg/24 hrs (reference range 0-6 mg/24 hrs).
METHODS: Cortisol and 5-HIAA
acid levels were measured by commercial enzyme-linked immunosorbent assay kits.
Sample contents of 5-HT, Trp and 5-HIAA
were determined using an HPLC electrochemical detection technique.
Clinically we could have measured serum peptide YY but this test is not available in our institute and we did not measure serum 5-HIAA
as the patient did not present with symptoms suggestive of carcinoid syndrome.
Symptom improvement was greatest for those receiving high-dose LX1031 who had at least a 15% reduction in 5-HIAA
levels, according to Dr.
levels may be a bio-marker that will serve as a potential guide to IBS therapy," Dr.
While the 5-HIAA
levels were related to impulsivity, the CSF testosterone levels were related to aggressiveness and interpersonal violence.
However, foregut carcinoids, which include bronchial carcinoids as well do not have increased 5-HIAA
levels, as was also seen in our study.
Some of these studies found a correlation between 5-HIAA
levels in the fluid bathing the brain (i.
Serial CTs over the next few years revealed no change in the two liver masses, and annual urinary 5-HIAA
levels remained within the normal range.
There was no significant change in the concentrations of 5-HIAA
and DOPAC after exposure to CAPs.