Notamment la di hydro testosterone qui resulte de la transformation de la testosterone sous l'effet d'une enzyme la 5 Alpha Reductase
Dihydrotestosterone is made from testosterone by 5 alpha reductase
enzyme, which is associated with male pattern baldness and health risks such as prostate growth.
Traish, of Boston University School of Medicine, examined data reported in various clinical studies from the available literature concerning the side effects of the 5 alpha reductase inhibitors, finasteride and dutasteride.
Young men are being prescribed 5 alpha reductase inhibitors as hair loss treatments that may negatively impact their sexual life, possibly for a prolonged time after stopping the medication.
Women who suffer from PCOS very frequently have an upregulation in the 5 alpha reductase
pathway--which is seen as an increase in the downstream metabolites driven by this enzyme.
AVODART belongs to a class of medicines known as 5 alpha reductase
inhibitors (5 ARIs), which shrink the prostate over time.
Selective nonsteroidal inhibitors of 5 alpha reductase
Krambeck: "After intervention, the greatest improvement in symptom score was seen in the TURP group, followed by laser vaporization, then the drugs, 5 alpha reductase
inhibitors and alpha adrenergic receptor blockers.
1) Finasteride only inhibits one of the 5 alpha reductase
(AR) enzymes, type 2.
This treatment benefit compares favorably to the mean symptom score improvement typically found after 3 months for currently approved BPH medications such as alpha blockers (in the 5 point range) and 5 alpha reductase
inhibitors (in the 3 point range).
Studies of alpha blockers and 5 alpha reductase
inhibitors have shown that these approved drugs are stopped by a large percentage of men who are prescribed them, due to intolerance of the side effects of the drugs such as dizziness, weakness, erectile dysfunction, loss of libido, retrograde ejaculation, gynecomastia, syncope, and many other frequent problems.