5'-nucleotidase


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5′-nucleotidase

[no̅o̅′klē·ot′idās]
an enzyme, elevated in some liver disorders and cancer of the pancreas. It is infrequently measured in the blood to diagnose certain liver and bone diseases. This enzyme is widely distributed throughout the body but is found in high concentrations in the liver and pancreas. The normal accumulation in serum is 0.1 to 6 units.

5'-nucleotidase

An enzyme present in the serum in abnormal amounts in diseases that affect the liver or obstruct the biliary tree.
Synonym: 5'- Ntase.
References in periodicals archive ?
Changes in serum activities of [gamma]-glutamyltransferase (GGT), 5'-nucleotidase (5NT), and the liver form of alkaline phosphatase (ALP) typically are associated with pathological processes of the liver (1).
GGT complexed to LDL and VLDL), 5'-nucleotidase, leucine aminopeptidase, cholinesterase, copper, iron, ferritin, and pseudouridine, using previously described procedures (2).
Lead inhibits heme biosynthesis and causes anemia, basophilic stippling, a decline in red cell 8-aminolevulinic acid dehydrogenase, and an increase in urinary 8-aminolevulinic acid, urinary coproporphyrin, red cell zinc protoporphyrin (ZPP), and pyrimidine 5'-nucleotidase (12).
One of the models indicated that in addition to significantly reducing infarct size, the preventive use of MPL-C significantly enhanced and preserved the activity of 5'-nucleotidase, an enzyme that helps to regulate adenosine metabolism.
5'-nucleotidase is an intrinsic membrane glycoprotein, present as an ectoenzyme in a wide variety of mammalian cells and it hydrolyzes extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels and is a regulator of the adenosine signaling pathway.
s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).
In the second assay, 5'-Nucleotidase activity was determined using the [[sup.
5'-Nucleotidase and [gamma]-glutamyl-transferase activity are used to confirm liver-specific origin of alkaline phosphatase.