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5'-nucleotidase

   Also found in: Wikipedia 0.01 sec.
5′-nucleotidase
[no̅o̅′klē·ot′idās]
a nonlipid enzyme, elevated in some liver disorders and cancer of the pancreas. It is infrequently measured in the blood to diagnose certain liver and bone diseases. This enzyme is widely distributed throughout the body but is found in high concentrations in the liver and pancreas. The normal accumulation in serum is 0.1 to 6 units.


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In particular, liver metastases are associated with increases in serum alkaline phosphatase, gamma-glutamyltransferase, and 5'-nucleotidase.
For this reason, it is often useful to measure another enzyme not found in these organs, either the 5'-nucleotidase (5'-NT) or the gamma-glutamyl transpeptidase (GGTP), along with the alkaline phosphatase when the origin of the elevated alkaline phosphatase (normal < 115 IU/1) is not clear.
 
 
 
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