dihydrofolate reductase

(redirected from 5,6,7,8-tetrahydrofolate dehydrogenase)
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di·hy·dro·fo·late re·duc·tase (DHFR),

(dī-hī'drō-fō'lāt rē-dŭk'tās), [MIM*126060]
An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate.
Synonym(s): 5, 6, 7, 8-tetrahydrofolate dehydrogenase

dihydrofolate reductase

An enzyme necessary for the synthesis of the purines of DNA.

dihydrofolate reductase

enzyme catalyzing the conversion of folate to 5,6,7,8-tetrahydrofolate, which is the key carrier of one-carbon units in purine and pyridime synthesis, the pathway for the breakdown of histidine and the synthesis of S-adenosylmethionine from S-adenosylhomocysteine. This enzyme is the target for methotrexate, which inhibits enzyme action, a key means of inducing remissions in acute leukemias.
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